null

SLC6A19 Antibody (PACO20525)

SKU:
PACO20525
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SLC6A19 Antibody PACO20525
  • SLC6A19 Antibody PACO20525
€339

Description

system_update_altDatasheetsystem_update_altMSDS

SLC6A19 Antibody (PACO20525)

The SLC6A19 Polyclonal Antibody (PACO20525) is a valuable tool for researchers studying SLC6A19, a solute carrier protein involved in amino acid transport. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SLC6A19 protein, this antibody enables precise detection and analysis in various cell types, making it an essential component for studies in the fields of molecular biology, biochemistry, and physiology.SLC6A19 is a crucial transporter protein responsible for the uptake of neutral amino acids in the intestine and kidney. Its role in amino acid absorption makes it a key player in processes such as protein synthesis and nitrogen metabolism.

Research on SLC6A19 is vital for understanding the mechanisms underlying amino acid homeostasis, as well as the development of targeted therapies for metabolic disorders and genetic diseases affecting amino acid transport.The SLC6A19 Polyclonal Antibody offers researchers a reliable tool for investigating the function and regulation of SLC6A19, providing valuable insights into amino acid transport and metabolism. By targeting this essential transporter protein, researchers can further their understanding of nutrient uptake and utilization, paving the way for advancements in the fields of nutrition, metabolism, and personalized medicine.

Antibody Name:SLC6A19 Antibody (PACO20525)
Antibody SKU:PACO20525
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:Human
Immunogen:Synthetic peptide of human SLC6A19
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20525(SLC6A19 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20525(SLC6A19 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acid, across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder.
Synonyms:solute carrier family 6 (neutral amino acid, transporter), member 19
UniProt Protein Function:SLC6A19: Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. Defects in SLC6A19 are a cause of Hartnup disorder (HND). HND is an autosomal recessive abnormality of renal and gastrointestinal neutral amino acid transport noted for its clinical variability. First described in 1956, HND is characterized by increases in the urinary and intestinal excretion of neutral amino acids. Individuals with typical Hartnup aminoaciduria may be asymptomatic, some develop a photosensitive pellagra-like rash, attacks of cerebellar ataxia and other neurological or psychiatric features. Although the definition of HND was originally based on clinical and biochemical abnormalities, its marked clinical heterogeneity has led to it being known as a disorder with a consistent pathognomonic neutral hyperaminoaciduria. Defects in SLC6A19 may be a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for hyperglycinuria. Defects in SLC6A19 may be a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-passChromosomal Location of Human Ortholog: 5p15.33Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: amino acid transmembrane transporter activity; neutral amino acid transmembrane transporter activityBiological Process: amino acid transportDisease: Hartnup Disorder; Hyperglycinuria; Iminoglycinuria
UniProt Protein Details:
NCBI Summary:This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008]
UniProt Code:Q695T7
NCBI GenInfo Identifier:73919285
NCBI Gene ID:340024
NCBI Accession:Q695T7.1
UniProt Secondary Accession:Q695T7,A8K446
UniProt Related Accession:Q695T7
Molecular Weight:71,110 Da
NCBI Full Name:Sodium-dependent neutral amino acid transporter B(0)AT1
NCBI Synonym Full Names:solute carrier family 6 member 19
NCBI Official Symbol:SLC6A19  
NCBI Official Synonym Symbols:HND; B0AT1  
NCBI Protein Information:sodium-dependent neutral amino acid transporter B(0)AT1
UniProt Protein Name:Sodium-dependent neutral amino acid transporter B(0)AT1
UniProt Synonym Protein Names:Solute carrier family 6 member 19; System B(0) neutral amino acid transporter AT1
Protein Family:Sodium-dependent neutral amino acid transporter
UniProt Gene Name:SLC6A19  
UniProt Entry Name:S6A19_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

Related Products