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SLC6A19 Antibody (PACO20524)

SKU:
PACO20524
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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SLC6A19 Antibody (PACO20524)

The SLC6A19 Polyclonal Antibody (PAC020524) is a valuable tool for researchers studying SLC6A19, a protein involved in amino acid transport and absorption in the intestine and kidney. This antibody, produced in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By targeting the SLC6A19 protein, researchers can investigate its role in amino acid metabolism and transport processes in various cell types, providing insights into metabolic disorders and renal diseases.SLC6A19 is crucial for the absorption of neutral amino acids in the small intestine and plays a vital role in maintaining amino acid homeostasis in the body.

Dysregulation of SLC6A19 function has been linked to amino acid malabsorption disorders and kidney diseases, highlighting its importance in nutrient uptake and renal function. Research on SLC6A19 with the PAC020524 antibody can shed light on the mechanisms underlying these conditions and aid in the development of therapies targeting amino acid transport pathways.

Antibody Name:SLC6A19 Antibody (PACO20524)
Antibody SKU:PACO20524
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:Human
Immunogen:Synthetic peptide of human SLC6A19
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20524(SLC6A19 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acid, across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder.
Synonyms:solute carrier family 6 (neutral amino acid, transporter), member 19
UniProt Protein Function:SLC6A19: Transporter that mediates epithelial resorption of neutral amino acids across the apical membrane of epithelial cells in the kidney and intestine. It appears that leucine is the preferred substrate, but all large neutral non-aromatic L-amino acids bind to this transporter. Uptake of leucine is sodium- dependent. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. Defects in SLC6A19 are a cause of Hartnup disorder (HND). HND is an autosomal recessive abnormality of renal and gastrointestinal neutral amino acid transport noted for its clinical variability. First described in 1956, HND is characterized by increases in the urinary and intestinal excretion of neutral amino acids. Individuals with typical Hartnup aminoaciduria may be asymptomatic, some develop a photosensitive pellagra-like rash, attacks of cerebellar ataxia and other neurological or psychiatric features. Although the definition of HND was originally based on clinical and biochemical abnormalities, its marked clinical heterogeneity has led to it being known as a disorder with a consistent pathognomonic neutral hyperaminoaciduria. Defects in SLC6A19 may be a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for hyperglycinuria. Defects in SLC6A19 may be a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. SLC6A19 deficiency combined with haploinsufficiency of SLC6A20 or partially inactivating mutations in SLC36A2, can be responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily.Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-passChromosomal Location of Human Ortholog: 5p15.33Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: amino acid transmembrane transporter activity; neutral amino acid transmembrane transporter activityBiological Process: amino acid transportDisease: Hartnup Disorder; Hyperglycinuria; Iminoglycinuria
UniProt Protein Details:
NCBI Summary:This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008]
UniProt Code:Q695T7
NCBI GenInfo Identifier:73919285
NCBI Gene ID:340024
NCBI Accession:Q695T7.1
UniProt Secondary Accession:Q695T7,A8K446
UniProt Related Accession:Q695T7
Molecular Weight:71,110 Da
NCBI Full Name:Sodium-dependent neutral amino acid transporter B(0)AT1
NCBI Synonym Full Names:solute carrier family 6 member 19
NCBI Official Symbol:SLC6A19  
NCBI Official Synonym Symbols:HND; B0AT1  
NCBI Protein Information:sodium-dependent neutral amino acid transporter B(0)AT1
UniProt Protein Name:Sodium-dependent neutral amino acid transporter B(0)AT1
UniProt Synonym Protein Names:Solute carrier family 6 member 19; System B(0) neutral amino acid transporter AT1
Protein Family:Sodium-dependent neutral amino acid transporter
UniProt Gene Name:SLC6A19  
UniProt Entry Name:S6A19_HUMAN
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