The SLC6A17 Antibody (PACO01815) is a polyclonal antibody designed for research involving the SLC6A17 protein, a member of the SLC6 family of transporters that play a crucial role in neurotransmitter uptake and signaling. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications.SLC6A17, also known as the solute carrier family 6 member 17, is involved in the transport of neurotransmitters such as GABA and taurine across cell membranes. This transport function is essential for proper neuronal communication and synaptic signaling in the brain.
The SLC6A17 Antibody enables the detection and analysis of SLC6A17 protein levels in various cell types, providing valuable insights into its role in neurotransmission and neurological disorders.Research into SLC6A17 is critical for understanding its impact on neurotransmitter balance and brain function, with implications for conditions like epilepsy, anxiety, and mood disorders. By studying the activity of SLC6A17, researchers can gain a better understanding of the mechanisms underlying these neurological conditions and potentially develop new therapeutic strategies targeting SLC6A17 function.
Antibody Name:
SLC6A17 Antibody
Antibody SKU:
PACO01815
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human NTT4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SLC6A17; NTT4; Sodium-dependent neutral amino acid transporter SLC6A17; Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17
UniProt Protein Function:
SLC6A17: Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A17 subfamily.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p13.3Cellular Component: integral to plasma membrane; synaptic vesicleMolecular Function: amino acid transmembrane transporter activityBiological Process: alanine transport; brain development; glycine transport; leucine transport; neutral amino acid transport; proline transportDisease: Mental Retardation, Autosomal Recessive 48
UniProt Protein Details:
NCBI Summary:
The SLC6 family of proteins, which includes SLC6A17, acts as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Mar 2008]
