The SLC6A16 Antibody (PAC040522) is a polyclonal antibody recommended for research involving SLC6A16, a solute carrier family member known for its role in ion transport and cellular homeostasis. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically targets the SLC6A16 protein, enabling precise detection and analysis in a variety of cell types, making it an essential tool for studies in physiology, pharmacology, and neuroscience.SLC6A16 is a key transporter protein responsible for the uptake of ions and neurotransmitters across cell membranes, playing a crucial role in maintaining cellular function and signaling.
Its involvement in ion transport regulation makes it a promising target for research in various fields, including neurobiology, metabolism, and kidney function. Understanding the function and regulation of SLC6A16 can provide insights into its potential implications in diseases related to ion imbalance, neurodegeneration, and metabolic disorders, paving the way for the development of novel therapeutic strategies.
Immunohistochemistry of paraffin-embedded human colon tissue using PACO40522 at dilution of 1:100.
Immunofluorescent analysis of A549 cells using PACO40522 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO40522 at dilution of 1:100.
Background:
integral component of plasma membrane, intracellular, amino acid, transmembrane transporter activity, neurotransmitter transporter activity, amino acid, transmembrane transport, neurotransmitter transport
Synonyms:
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 (Solute carrier family 6 member 16), SLC6A16, NTT5
UniProt Protein Function:
SLC6A16: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A16 subfamilyProtein type: Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 19q13.33Cellular Component: integral to membrane; intracellularMolecular Function: neurotransmitter:sodium symporter activity; neurotransmitter transporter activityBiological Process: neurotransmitter transport; transmembrane transport
UniProt Protein Details:
NCBI Summary:
SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]
