The SLC52A1 Polyclonal Antibody (PAC041442) is specifically designed for research involving SLC52A1, a protein involved in the transport of riboflavin (vitamin B2) into cells. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the SLC52A1 protein, it allows for the detection and analysis of this crucial transporter in various cell types, making it an essential tool for studies in metabolism and nutrient uptake.SLC52A1, also known as Riboflavin Transporter 1 (RFVT1), plays a pivotal role in maintaining cellular levels of riboflavin, a vital nutrient involved in various physiological processes such as energy production and antioxidant defense.
Understanding the function of SLC52A1 is important in elucidating the mechanisms underlying riboflavin deficiency and its implications for health and disease. Research on SLC52A1 may offer insights into metabolic disorders, neurological conditions, and other diseases related to riboflavin metabolism.
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO41442 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO41442 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human gastric cancer using PACO41442 at dilution of 1:100.
Background:
Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
Synonyms:
Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1), SLC52A1, GPR172B PAR2 RFT1
UniProt Protein Function:
GPR172B: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Haploinsufficiency in SLC52A1 can cause maternal riboflavin deficiency. In the newborn infant, this can lead to a transient riboflavin-responsive disorder with clinical and biochemical features of multiple acyl-CoA dehydrogenase deficiency. Belongs to the riboflavin transporter family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.2Cellular Component: integral to plasma membraneMolecular Function: riboflavin transporter activity; viral receptor activityBiological Process: entry of virus into host cell; riboflavin transportDisease: Riboflavin Deficiency
UniProt Protein Details:
NCBI Summary:
Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
