The SLC52A1 Polyclonal Antibody (PAC019736) is a valuable tool for researchers studying SLC52A1, a key transporter protein involved in the uptake of riboflavin (vitamin B2) into cells. This antibody, produced in rabbits, has high specificity for human samples and has been rigorously validated for Western blot applications. By binding to the SLC52A1 protein, this antibody allows for the detection and analysis of SLC52A1 in a variety of cell types, making it an ideal choice for studies in the fields of nutrition and metabolism.SLC52A1 is essential for the absorption of riboflavin, a vital micronutrient involved in numerous biological processes such as energy production and antioxidant defense.
Dysregulation of SLC52A1 has been linked to conditions like riboflavin deficiency and certain metabolic disorders. Research into the function and regulation of SLC52A1 is crucial for understanding how riboflavin is transported into cells and how its deficiency can impact human health. This antibody provides researchers with a powerful tool to further explore the role of SLC52A1 in various physiological and pathological conditions.
Antibody Name:
SLC52A1 Antibody (PACO19736)
Antibody SKU:
PACO19736
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SLC52A1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19736(SLC52A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19736(SLC52A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms:
solute carrier family 52 (riboflavin transporter), member 1
UniProt Protein Function:
GPR172B: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Haploinsufficiency in SLC52A1 can cause maternal riboflavin deficiency. In the newborn infant, this can lead to a transient riboflavin-responsive disorder with clinical and biochemical features of multiple acyl-CoA dehydrogenase deficiency. Belongs to the riboflavin transporter family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.2Cellular Component: integral to plasma membraneMolecular Function: riboflavin transporter activity; viral receptor activityBiological Process: entry of virus into host cell; riboflavin transportDisease: Riboflavin Deficiency
UniProt Protein Details:
NCBI Summary:
Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
