The SLC52A1 Antibody (PAC019735) is a critical tool for researchers studying the SLC52A1 protein, a key player in the transport of riboflavin (vitamin B2) into cells. This polyclonal antibody, generated in rabbits, has high specificity and sensitivity for human samples, making it an excellent choice for Western blot applications. By binding to the SLC52A1 protein, this antibody enables the detection and analysis of SLC52A1 in various cell types, facilitating research in areas such as metabolism, nutrition, and genetic disorders.SLC52A1, also known as riboflavin transporter 1, is essential for the uptake of riboflavin, a critical nutrient involved in energy production and cellular metabolism.
Disruption of SLC52A1 function has been linked to riboflavin deficiency disorders and metabolic disturbances. The ability to study SLC52A1 expression and activity is vital for understanding its role in health and disease, with implications for developing targeted therapies and nutritional interventions. Researchers interested in riboflavin metabolism and its impact on human health will find the SLC52A1 Antibody an invaluable tool for their studies.
Antibody Name:
SLC52A1 Antibody (PACO19735)
Antibody SKU:
PACO19735
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SLC52A1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO19735(SLC52A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19735(SLC52A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms:
solute carrier family 52 (riboflavin transporter), member 1
UniProt Protein Function:
GPR172B: Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). Haploinsufficiency in SLC52A1 can cause maternal riboflavin deficiency. In the newborn infant, this can lead to a transient riboflavin-responsive disorder with clinical and biochemical features of multiple acyl-CoA dehydrogenase deficiency. Belongs to the riboflavin transporter family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 17p13.2Cellular Component: integral to plasma membraneMolecular Function: riboflavin transporter activity; viral receptor activityBiological Process: entry of virus into host cell; riboflavin transportDisease: Riboflavin Deficiency
UniProt Protein Details:
NCBI Summary:
Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
