The SLC51A Polyclonal Antibody (PAC047978) is a valuable tool for researchers studying SLC51A, a transmembrane protein involved in bile acid transport and regulation. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for Western blot applications. By binding to the SLC51A protein, researchers can easily detect and analyze its expression in various cell types.SLC51A plays a crucial role in the enterohepatic circulation of bile acids, impacting lipid metabolism and cholesterol homeostasis. Dysregulation of SLC51A has been linked to liver diseases, including cholestasis and non-alcoholic fatty liver disease, making it a promising target for therapeutic interventions.
Understanding the function and expression of SLC51A is essential for developing new treatments for these conditions.Overall, the SLC51A Polyclonal Antibody is a valuable tool for researchers studying bile acid metabolism, liver diseases, and lipid metabolism. Its high specificity and reactivity make it a reliable choice for Western blotting experiments, providing crucial insights into the role of SLC51A in health and disease.
Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO47978 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO47978 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Essential component of the Ost-alpha/Ost-β complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid, export from enterocytes into portal blood. Efficiently transports the major species of bile acid,.
Synonyms:
Organic solute transporter subunit α (OST-alpha) (Solute carrier family 51 subunit alpha), SLC51A, OSTA
UniProt Protein Function:
OSTalpha: Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Belongs to the OST-alpha family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3q29Cellular Component: endoplasmic reticulum membrane; integral to membrane; plasma membrane; protein complexMolecular Function: protein heterodimerization activity; protein homodimerization activity; transporter activityBiological Process: bile acid and bile salt transport; transport
