The SLC4A9 Polyclonal Antibody (PAC050858) is a valuable tool for researchers studying the SLC4A9 protein, a member of the solute carrier family involved in ion transport and pH regulation. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. It binds to the SLC4A9 protein, allowing for accurate detection and analysis in various cell types, making it an essential component for studies in physiology, nephrology, and cancer research.
SLC4A9, also known as Sodium Bicarbonate Cotransporter 9, plays a crucial role in maintaining pH balance in the body through the transport of sodium and bicarbonate ions across cell membranes. Dysregulation of SLC4A9 has been linked to various diseases, including renal disorders and cancer. By understanding the function of SLC4A9, researchers can uncover new therapeutic targets for treating these conditions and improving patient outcomes.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO50858 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO50858 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Probable apical anion exchanger of the kidney cortex.
Synonyms:
Anion exchange protein 4 (AE 4) (Anion exchanger 4) (Sodium bicarbonate cotransporter 5) (Solute carrier family 4 member 9), SLC4A9, AE4 SBC5
UniProt Protein Function:
SLC4A9: Probable apical anion exchanger of the kidney cortex. Belongs to the anion exchanger (TC 2.A.31) family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; TransporterChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: anion transmembrane transporter activity; sodium:bicarbonate symporter activityBiological Process: bicarbonate transport; regulation of intracellular pH
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
