SLC4A8/SLC4A10 Antibody (PACO03035)
- SKU:
- PACO03035
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC4A8/SLC4A10 Antibody (PACO03035)
The SLC4A8/SLC4A10 Polyclonal Antibody (PACO03035) is a powerful tool for researchers studying the function of SLC4A8 and SLC4A10, two solute carrier proteins involved in ion transportation and pH regulation within cells. This antibody is produced in rabbits and has been extensively validated for Western blot applications with human samples.SLC4A8 and SLC4A10 are essential for maintaining proper cellular pH balance and are implicated in various physiological processes, including renal function, neuronal signaling, and acid-base homeostasis. By targeting these proteins with the PACO03035 antibody, researchers can accurately detect and analyze SLC4A8 and SLC4A10 expression in different cell types, providing valuable insights into their roles in health and disease.
Given the importance of SLC4A8 and SLC4A10 in cellular function, this antibody is a valuable tool for studies in biology, physiology, and pathology to further understand the mechanisms underlying ion transport and pH regulation. Researchers can use this antibody to explore the potential therapeutic implications of targeting SLC4A8 and SLC4A10 in conditions such as kidney disease, neurological disorders, and metabolic syndromes.
| Antibody Name: | SLC4A8/SLC4A10 Antibody |
| Antibody SKU: | PACO03035 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human SLC4A8/10. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | SLC4A8; KIAA0739; NBC; NBC3; NDCBE1; Electroneutral sodium bicarbonate exchanger 1; Electroneutral Na(+)-driven Cl-HCO3 exchanger; Solute carrier family 4 member 8; k-NBC3; SLC4A10; NCBE; Sodium-driven chloride bicarbonate exchanger; Solute |
| UniProt Protein Function: | SLC4A8: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. Belongs to the anion exchanger (TC 2.A.31) family. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: neuron projection; integral to plasma membrane; plasma membrane Molecular Function:inorganic anion exchanger activity; sodium:bicarbonate symporter activity Biological Process: bicarbonate transport; regulation of intracellular pH; ion transport; transmembrane transport |
| NCBI Summary: | The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q2Y0W8 |
| NCBI GenInfo Identifier: | 90403614 |
| NCBI Gene ID: | 9498 |
| NCBI Accession: | NP_001035049.1 |
| UniProt Secondary Accession: | Q2Y0W8,O94843, O95233, Q004B4, Q8N3U2, Q8TC60, Q9UKX8 A0MMZ1, B4DHY0, E7EML0, F5GZ31, F5H7F5, |
| UniProt Related Accession: | Q2Y0W8 |
| Molecular Weight: | 122938 |
| NCBI Full Name: | electroneutral sodium bicarbonate exchanger 1 isoform a |
| NCBI Synonym Full Names: | solute carrier family 4, sodium bicarbonate cotransporter, member 8 |
| NCBI Official Symbol: | SLC4A8Â Â |
| NCBI Official Synonym Symbols: | NBC3; NDCBEÂ Â |
| NCBI Protein Information: | electroneutral sodium bicarbonate exchanger 1 |
| UniProt Protein Name: | Electroneutral sodium bicarbonate exchanger 1 |
| UniProt Synonym Protein Names: | Electroneutral Na(+)-driven Cl-HCO3 exchanger; Solute carrier family 4 member 8; k-NBC3 |
| UniProt Gene Name: | SLC4A8Â Â |
| UniProt Entry Name: | S4A8_HUMAN |
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