The SLC4A5 Polyclonal Antibody (CAB10436) is a valuable tool for researchers studying the SLC4A5 protein, a member of the solute carrier family known for its role in ion transport and pH regulation in the kidney. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By binding specifically to the SLC4A5 protein, this antibody enables the detection and analysis of SLC4A5 in various cell types, providing insights into its function in kidney physiology and potential implications in renal diseases.SLC4A5, also known as the electrogenic sodium bicarbonate cotransporter 1 (NBCe1), plays a crucial role in maintaining acid-base balance in the body by regulating the transport of sodium and bicarbonate ions across cell membranes.
Dysregulation of SLC4A5 function has been linked to disorders such as renal tubular acidosis and hypertension, highlighting its importance in renal health. By studying the expression and activity of SLC4A5 using this polyclonal antibody, researchers can uncover new insights into its physiological and pathological roles, paving the way for the development of targeted therapies for kidney-related conditions.
Product Name:
SLC4A5 Rabbit Polyclonal Antibody
SKU:
CAB10436
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1042-1121 of human SLC4A5 (NP_597812.1).
This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
57835
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC4A5 Rabbit pAb (CAB10436) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
