The SLC4A4 Polyclonal Antibody (CAB5332) is a powerful research tool designed for studying SLC4A4, a key protein involved in ion transport and pH regulation in cells. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications, allowing for accurate detection and analysis of SLC4A4 expression.SLC4A4, also known as sodium bicarbonate cotransporter, plays a crucial role in maintaining cellular pH balance by regulating the transport of sodium and bicarbonate ions across cell membranes. Dysregulation of SLC4A4 has been linked to various diseases such as metabolic disorders, kidney stones, and certain cancers.
Research into the function and expression of SLC4A4 is essential for understanding its role in health and disease.With its high reactivity and specificity, the SLC4A4 Polyclonal Antibody is an invaluable tool for researchers studying ion transport, pH regulation, and related cellular processes. Its versatility in various cell types makes it ideal for investigations in physiology, cell biology, and disease mechanisms related to SLC4A4 function.
Product Name:
SLC4A4/NBC Rabbit Polyclonal Antibody
SKU:
CAB5332
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 978-1078 of human SLC4A4 / NBC (NP_001091954.1).
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8671
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from LNCaP cells, using SLC4A4 / NBC Rabbit pAb (CAB5332) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
