The SLC4A2 Polyclonal Antibody (CAB7729) is a valuable tool for researchers studying SLC4A2, a key transporter protein involved in ion and pH regulation in various tissues, including the kidneys and the central nervous system. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.SLC4A2, also known as the sodium bicarbonate cotransporter 2 (NBCe1), plays a crucial role in maintaining cellular pH balance and electrolyte transport. Dysregulation of SLC4A2 has been linked to various human diseases, including renal tubular acidosis and neurological disorders.
This antibody binds specifically to the SLC4A2 protein, allowing for precise detection and analysis in different cell types.Research into SLC4A2 function is essential for understanding its role in normal physiology and disease pathology. The SLC4A2 Polyclonal Antibody provides researchers with a reliable tool to explore the molecular mechanisms underlying SLC4A2-mediated ion transport and its implications for health and disease. This antibody is an invaluable resource for studies in physiology, neuroscience, and disorders related to electrolyte and pH imbalance.
Product Name:
SLC4A2 Rabbit Polyclonal Antibody
SKU:
CAB7729
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human SLC4A2 (NP_001186623.1).
This gene encodes a member of the anion exchanger family of membrane transport proteins. The encoded protein regulates intracellular pH, biliary bicarbonate secretion, and chloride uptake. Reduced expression of this gene may be associated with primary biliary cirrhosis (PBC) in human patients, while differential expression of this gene may be associated with malignant hepatocellular carcinoma, colon and gastric cancers.
Purification Method:
Affinity purification
Gene ID:
6522
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC4A2 Rabbit pAb (CAB7729) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
