The SLC4A11 Polyclonal Antibody (CAB15910) is specifically designed for research involving SLC4A11, a membrane transport protein that plays a crucial role in maintaining corneal transparency and fluid homeostasis. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications.SLC4A11 is known to be associated with several corneal dystrophies and abnormalities, making it a significant target for studies in ophthalmology and eye diseases. By binding to SLC4A11 protein, this antibody enables accurate detection and analysis of its expression in various cell types, providing researchers with valuable insights into its function and potential role in disease pathology.
Understanding the role of SLC4A11 in maintaining corneal health and transparency is essential for the development of targeted therapies and treatments for individuals with related disorders. By utilizing the SLC4A11 Polyclonal Antibody (CAB15910), researchers can further explore the mechanisms involved in SLC4A11-mediated transport processes and their impact on ocular health.
Product Name:
SLC4A11 Rabbit Polyclonal Antibody
SKU:
CAB15910
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC4A11 (NP_001167560.1).
This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
83959
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using SLC4A11 Rabbit pAb (CAB15910) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
