The SLC4A10/SLC4A8 Polyclonal Antibody (PACO22625) is a valuable tool for researchers studying SLC4A10 and SLC4A8, two important transporters involved in ion exchange and pH regulation in cells. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting both SLC4A10 and SLC4A8 proteins in human samples, making it suitable for use in Western blot applications.SLC4A10 and SLC4A8 play crucial roles in maintaining cellular pH homeostasis and are implicated in various physiological processes, including electrolyte transport and acid-base balance. Dysregulation of these transporters has been linked to diseases such as hypertension, neurological disorders, and certain cancers.
By targeting SLC4A10 and SLC4A8 with this antibody, researchers can gain insights into their functions and explore their potential as therapeutic targets in the treatment of related diseases.For scientists conducting studies in the fields of physiology, pharmacology, and cell biology, the SLC4A10/SLC4A8 Polyclonal Antibody offers a reliable tool for investigating the molecular mechanisms underlying ion transport and pH regulation. Its specificity and versatility make it an essential component of any research project aiming to elucidate the roles of SLC4A10 and SLC4A8 in health and disease.
Antibody Name:
SLC4A10/SLC4A8 Antibody (PACO22625)
Antibody SKU:
PACO22625
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human SLC4A8/10.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, using SLC4A8/10 antibody.
Background:
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH By similarity.
Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH.
NCBI Summary:
This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
