SLC46A1 Polyclonal Antibody (CAB7397)
- SKU:
- CAB7397
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | SLC46A1 Polyclonal Antibody |
SKU: | CAB7397 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SLC46A1 (NP_001229295.1). |
Sequence: | MEGS ASPP EKPR ARPA AAVL CRGP VEPL VFLA NFAL VLQG PLTT QYLW HRFS ADLG YNGT RQRG GCSN RSAD PTMQ EVET LTSH WTLY MNVG GFLV GLFS STLL GAWS DSVG RRPL LVLA SLGL LLQA LV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | G21; HCP1; PCFT; hPCFT; HsPCFT; SLC46A1 |
Positive Sample: | HL-60(Negative control),Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Apical cell membrane, Cytoplasm, Multi-pass membrane protein. |
Calculated MW: | 50kDa |
Observed MW: | 55kDa |
This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 113235 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |