The SLC43A1 Polyclonal Antibody (PACO21699) is a valuable tool for researchers studying SLC43A1, a member of the SLC43 family of amino acid transporters. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the SLC43A1 protein, this antibody enables researchers to detect and analyze the expression of SLC43A1 in various cell types, offering insight into its role in amino acid transport and metabolism.SLC43A1 plays a crucial role in the cellular uptake of amino acids, making it a key player in regulating cellular metabolism and growth.
Its dysregulation has been implicated in various diseases, including cancer and metabolic disorders. By studying SLC43A1, researchers can gain a better understanding of how amino acid transport contributes to disease pathology and potentially identify new therapeutic targets.Overall, the SLC43A1 Polyclonal Antibody (PACO21699) is a valuable tool for researchers interested in exploring the role of SLC43A1 in health and disease. Its high specificity and sensitivity make it ideal for a wide range of research applications, from basic science to drug development.
Antibody Name:
SLC43A1 Antibody (PACO21699)
Antibody SKU:
PACO21699
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human LAT3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells and A549 cells, using LAT3 antibody.
Background:
Sodium-independent, high affinity transport of large neutral amino acid, . Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acid, and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. Babu E., J. Biol. Chem. 278:43838-43845(2003).
Synonyms:
L-type amino acid, transporter 3; LAT3; large neutral amino acid, transporter small subunit 3; prostate cancer overexpressed gene 1 protein; solute carrier family 43 member 1
UniProt Protein Function:
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.
NCBI Summary:
SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]
