The SLC41A2 Polyclonal Antibody (PAC020511) is a reliable tool designed for researchers studying the SLC41A2 protein, which plays a crucial role in magnesium transport within cells. This antibody is produced in rabbits and has been shown to exhibit high reactivity with human samples, making it an excellent choice for Western blot applications. By targeting the SLC41A2 protein, researchers can accurately detect and analyze its expression in various cell types, providing valuable insights for studies in physiology, metabolism, and related fields.SLC41A2 is a key player in maintaining magnesium homeostasis, a vital process for cell function and overall health.
Dysregulation of magnesium transport has been linked to various health conditions, including cardiovascular disease, diabetes, and neurological disorders. By investigating the functions of SLC41A2, researchers can uncover potential therapeutic targets and pathways for the treatment of these diseases.The SLC41A2 Polyclonal Antibody is an essential tool for researchers seeking to deepen their understanding of magnesium transport mechanisms and their impact on human health. Its ability to specifically bind to the SLC41A2 protein makes it a valuable asset for anyone working in the fields of biochemistry, molecular biology, and medical research.
Antibody Name:
SLC41A2 Antibody (PACO20511)
Antibody SKU:
PACO20511
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:20-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SLC41A2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20511(SLC41A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20511(SLC41A2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC41A2 (solute carrier family 41, member 2), also known as SLC41A1-L, is a 573 amino acid, multi-pass membrane protein that belongs to the SLC41A transporter family that includes SLC41A1 and SLC41A3. Expressed in lymphocytes and localizing to the cell membrane, SLC41A2 contains twelve transmembrane domains, three myristoylation sequences, numerous possible phosphorylation sites and a putative N-glycosylation site. SLC41A2 is believed to function as a plasma-membrane magnesium transporter. Magnesium, a cofactor for ATP, plays a vital role in metabolic and biochemical processes. The transport of magnesium across membranes is essential for maintaining magnesium homeostasis and is fundamental to vertebrate metabolism.
Synonyms:
solute carrier family 41 (magnesium transporter), member 2
UniProt Protein Function:
SLC41A2: Acts as a plasma-membrane magnesium transporter. Belongs to the SLC41A transporter family.Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Channel, cation; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12q23.3Cellular Component: plasma membraneMolecular Function: magnesium ion transmembrane transporter activity; protein bindingBiological Process: transmembrane transport
