The SLC41A2 Polyclonal Antibody (PAC020510) is a valuable tool for researchers studying SLC41A2, a key transporter protein involved in cellular magnesium homeostasis. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the SLC41A2 protein, this antibody enables the detection and analysis of SLC41A2 in various cell types, facilitating research in the fields of physiology, metabolism, and disease.SLC41A2 is crucial for maintaining proper magnesium levels within cells, playing a critical role in processes such as enzymatic reactions, signal transduction, and ion channel activity.
Dysregulation of SLC41A2 has been linked to various disorders, including cardiovascular disease, diabetes, and neurological conditions. By studying the function and regulation of SLC41A2, researchers can gain insights into the mechanisms underlying these diseases and potentially identify therapeutic targets for intervention.
Antibody Name:
SLC41A2 Antibody (PACO20510)
Antibody SKU:
PACO20510
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:40-1:150
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human SLC41A2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20510(SLC41A2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20510(SLC41A2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC41A2 (solute carrier family 41, member 2), also known as SLC41A1-L, is a 573 amino acid, multi-pass membrane protein that belongs to the SLC41A transporter family that includes SLC41A1 and SLC41A3. Expressed in lymphocytes and localizing to the cell membrane, SLC41A2 contains twelve transmembrane domains, three myristoylation sequences, numerous possible phosphorylation sites and a putative N-glycosylation site. SLC41A2 is believed to function as a plasma-membrane magnesium transporter. Magnesium, a cofactor for ATP, plays a vital role in metabolic and biochemical processes. The transport of magnesium across membranes is essential for maintaining magnesium homeostasis and is fundamental to vertebrate metabolism.
Synonyms:
solute carrier family 41 (magnesium transporter), member 2
UniProt Protein Function:
SLC41A2: Acts as a plasma-membrane magnesium transporter. Belongs to the SLC41A transporter family.Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Channel, cation; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12q23.3Cellular Component: plasma membraneMolecular Function: magnesium ion transmembrane transporter activity; protein bindingBiological Process: transmembrane transport
