The SLC41A1 Polyclonal Antibody (PAC059217) is a valuable tool for researchers studying the SLC41A1 protein, which is involved in cellular uptake and transport of divalent metal ions. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SLC41A1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in areas such as cell biology and metal ion homeostasis.SLC41A1, also known as solute carrier family 41 member 1, plays a crucial role in regulating the intracellular levels of magnesium and manganese ions, which are essential for various cellular functions.
Dysregulation of SLC41A1 has been implicated in conditions such as neurodegenerative diseases and metabolic disorders. Therefore, elucidating the mechanisms underlying SLC41A1 function is key to developing targeted therapies for these conditions.The SLC41A1 Polyclonal Antibody provides researchers with a powerful tool to investigate the role of SLC41A1 in health and disease, ultimately contributing to the advancement of scientific knowledge and potential therapeutic interventions.
IHC image of PACO59217 diluted at 1:400 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of HepG2 cells with PACO59217 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Acts as a magnesium transporter that is responsive to magnesium balance.
Synonyms:
Solute carrier family 41 member 1, SLC41A1
UniProt Protein Function:
SLC41A1: Acts as a magnesium transporter that is responsive to magnesium balance. Belongs to the SLC41A transporter family.Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC familyChromosomal Location of Human Ortholog: 1q32.1Cellular Component: integral to membrane; plasma membraneMolecular Function: cation transmembrane transporter activityBiological Process: transmembrane transport
