The SLC39A8 Polyclonal Antibody (CAB10395) is a valuable tool for research involving SLC39A8, a zinc transporter protein essential for cellular zinc homeostasis. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the SLC39A8 protein, this antibody enables the detection and analysis of SLC39A8 in various cell types, facilitating studies in the fields of cellular biology and metabolism.SLC39A8 plays a crucial role in the regulation of zinc levels within cells, contributing to numerous physiological processes such as growth, development, and immune function.
Dysregulation of SLC39A8 has been implicated in various diseases, including metabolic disorders and neurological conditions. Therefore, research on SLC39A8 is vital for gaining insights into these disease mechanisms and developing potential therapeutic interventions targeting zinc homeostasis.Overall, the SLC39A8 Polyclonal Antibody (CAB10395) is a reliable tool for researchers interested in studying the function and regulation of SLC39A8 in health and disease. Its specificity and sensitivity make it a valuable asset for investigations aiming to uncover the role of zinc transporters in cellular physiology and pathophysiology.
Product Name:
ZIP8 Rabbit Polyclonal Antibody
SKU:
CAB10395
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-300 of human ZIP8 (NP_071437.3).
This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
Purification Method:
Affinity purification
Gene ID:
64116
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ZIP8 antibody (CAB10395) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
