The SLC39A3 Polyclonal Antibody (PAC020505) is a vital tool for research in the field of cellular transport and metal ion homeostasis. This antibody, produced against SLC39A3, a zinc transporter protein, exhibits high reactivity towards human samples and is suitable for Western blot applications. By specifically binding to the SLC39A3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in biochemistry and molecular biology.SLC39A3, also known as ZIP3, plays a crucial role in cellular zinc homeostasis by facilitating the transport of zinc ions across cell membranes. Dysregulation of zinc transporters like SLC39A3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and diabetes.
Investigating the function of SLC39A3 can provide valuable insights into the mechanisms underlying these conditions and may lead to the development of targeted therapies aimed at restoring zinc balance in affected cells.In summary, the SLC39A3 Polyclonal Antibody (PAC020505) is a valuable research tool for scientists studying zinc transport and its implications in human health and disease. Its high specificity and reactivity make it an ideal choice for investigating the role of SLC39A3 in various cellular processes, offering new avenues for therapeutic interventions and disease management.
Antibody Name:
SLC39A3 Antibody (PACO20505)
Antibody SKU:
PACO20505
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human SLC39A3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20505(SLC39A3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20505(SLC39A3 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC39A3 (solute carrier family 39, member 2), is a 314 amino acid, acid, multi-pass membrane protein that localizes to the cell membrane and belongs to the ZIP family of zinc transporters. Two isoforms of ZIP3 exist as a result of alternative splicing events. ZIP3 is involved in translocation of extracellular zinc into a variety of cell types. Tumorigenic prostate epithelial cells contain less intracellular zinc than non-tumorigenic prostate epithelial cells. Loss of the ability to maintain zinc accumulation may be caused by the decrease in the ZIP1 protein expression and the intracellular redistribution of ZIP3.
Synonyms:
solute carrier family 39 (zinc transporter), member 3
UniProt Protein Function:
SLC39A3: Acts as a zinc-influx transporter (Potential). Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 19p13.3Cellular Component: plasma membraneMolecular Function: zinc ion transmembrane transporter activity
