The SLC39A3 Monoclonal Antibody (PAC020504) is specifically designed for research involving SLC39A3, a member of the SLC39 zinc transporter family that plays a crucial role in cellular zinc homeostasis. This antibody, produced through monoclonal antibody technology, has high specificity and sensitivity for detecting human SLC39A3 protein in various samples.SLC39A3 is known to be involved in zinc transport across cell membranes and is essential for maintaining zinc levels within cells, which is important for various cellular processes including DNA replication, transcription, and cell proliferation.
Dysregulation of SLC39A3 has been linked to various diseases, including cancer, neurodegenerative disorders, and diabetes.The SLC39A3 Monoclonal Antibody is validated for use in Western blot applications and can be used to study the expression and function of SLC39A3 in different cell types and tissues. Its high specificity and sensitivity make it a valuable tool for researchers in the fields of molecular biology, biochemistry, and cell biology who are investigating the role of SLC39A3 in health and disease.
Antibody Name:
SLC39A3 Antibody (PACO20504)
Antibody SKU:
PACO20504
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:20-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human SLC39A3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20504(SLC39A3 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC39A3 (solute carrier family 39, member 2), is a 314 amino acid, acid, multi-pass membrane protein that localizes to the cell membrane and belongs to the ZIP family of zinc transporters. Two isoforms of ZIP3 exist as a result of alternative splicing events. ZIP3 is involved in translocation of extracellular zinc into a variety of cell types. Tumorigenic prostate epithelial cells contain less intracellular zinc than non-tumorigenic prostate epithelial cells. Loss of the ability to maintain zinc accumulation may be caused by the decrease in the ZIP1 protein expression and the intracellular redistribution of ZIP3.
Synonyms:
solute carrier family 39 (zinc transporter), member 3
UniProt Protein Function:
SLC39A3: Acts as a zinc-influx transporter (Potential). Belongs to the ZIP transporter (TC 2.A.5) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 19p13.3Cellular Component: plasma membraneMolecular Function: zinc ion transmembrane transporter activity
