The SLC39A14 Polyclonal Antibody (CAB10413) is a vital tool for researchers studying SLC39A14, a zinc transporter protein involved in cellular zinc homeostasis. This antibody, generated in rabbits, exhibits high specificity towards human samples and is validated for use in Western blot applications. By binding to the SLC39A14 protein, researchers are able to detect and analyze its expression in different cell types, making it an essential tool for studies in zinc metabolism and its role in various cellular processes.SLC39A14 is known for its role in facilitating the transport of zinc into cells, which is essential for numerous biological functions including DNA synthesis, enzyme activity, and immune function.
Dysregulation of cellular zinc levels has been linked to a variety of health conditions, highlighting the importance of studying SLC39A14 and its impact on overall health and disease. This antibody provides researchers with the ability to investigate the function of SLC39A14 in different physiological and pathological contexts, ultimately leading to a better understanding of zinc homeostasis and its implications for human health.
Product Name:
ZIP14 Rabbit Polyclonal Antibody
SKU:
CAB10413
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 101-200 of human ZIP14 (NP_001121903.1).
This gene encodes a member of the the SLC39A family of divalent metal transporters that mediates the cellular uptake of manganese, zinc, iron, and cadmium. The encoded protein contains eight transmembrane domains, a histidine-rich motif, and a metalloprotease motif, and is expressed on the plasma membrane and the endocytic vesicle membrane. It is an important transporter of nontransferrin-bound iron and a critical regulator of manganese homeostasis. Naturally occurring mutations in this gene are associated with neurodegeneration with brain iron accumulation and early-onset parkinsonism-dystonia with hypermanganesemia.
Purification Method:
Affinity purification
Gene ID:
23516
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ZIP14 Rabbit pAb (CAB10413) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
