The SLC39A1 Polyclonal Antibody (PACO03884) is a valuable tool for researchers studying the SLC39A1 protein, also known as ZIP1, which plays a crucial role in zinc homeostasis and cellular uptake. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SLC39A1 protein, this antibody enables researchers to detect and analyze SLC39A1 expression in various cell types, making it ideal for studies in cellular biology, metabolism, and metal ion transport.SLC39A1 is a member of the SLC39 family of zinc transporters, responsible for regulating the intracellular levels of zinc, an essential micronutrient crucial for numerous cellular processes.
Dysregulation of zinc homeostasis has been implicated in a variety of diseases, including cancer, diabetes, and neurodegenerative disorders. Research into the function of SLC39A1 can provide valuable insights into the role of zinc in health and disease, as well as potential therapeutic targets for zinc-related disorders. The SLC39A1 Polyclonal Antibody is a reliable tool for scientists seeking to further understand the intricate mechanisms of zinc transport and its implications for human health. Its specificity and high sensitivity make it an essential component for studies aimed at unraveling the complex interplay between SLC39A1 and cellular zinc signaling pathways.
Antibody Name:
SLC39A1 Antibody
Antibody SKU:
PACO03884
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human ZIP1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SLC39A1; IRT1; ZIP1; ZIRTL; CGI-08; CGI-71; Zinc transporter ZIP1; Solute carrier family 39 member 1; Zinc-iron-regulated transporter-like; Zrt- and Irt-like protein 1; ZIP-1; hZIP1
UniProt Protein Function:
SLC39A1: Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells. Belongs to the ZIP transporter (TC 2.A.5) family.Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1q21Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane; plasma membraneMolecular Function: inorganic cation transmembrane transporter activity; zinc ion transmembrane transporter activity; receptor bindingBiological Process: transmembrane transport; cation transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
