Background: | Lysosomal amino acid, transporter involved in the activation of mTORC1 in response to amino acid,. Probably acts as an amino acid, sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid, sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acid,. Following activation by amino acid, , the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acid, with low capacity and specificity with a slight preference for polar amino acid, , suggesting that it acts as an amino acid, sensor instead. The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor. |
Synonyms: | Sodium-coupled neutral amino acid, transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11), SLC38A9, URLC11 |
UniProt Protein Function: | SLC38A9: Putative sodium-dependent amino acid/proton antiporter. Belongs to the amino acid/polyamine transporter 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-passChromosomal Location of Human Ortholog: 5q11.2Cellular Component: endoplasmic reticulum; late endosome; lysosomeMolecular Function: amino acid transmembrane transporter activity; protein bindingBiological Process: positive regulation of TOR signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q8NBW4 |
NCBI GenInfo Identifier: | 385137120 |
NCBI Gene ID: | 153129 |
NCBI Accession: | NP_001245215.1 |
UniProt Secondary Accession: | Q8NBW4,Q0P5S0, Q6MZJ8, A0A0A8K8P2, B3KXV1, B7Z7D0 |
UniProt Related Accession: | Q8NBW4 |
Molecular Weight: | 56,695 Da |
NCBI Full Name: | sodium-coupled neutral amino acid transporter 9 isoform 2 |
NCBI Synonym Full Names: | solute carrier family 38 member 9 |
NCBI Official Symbol: | SLC38A9Â Â |
NCBI Official Synonym Symbols: | URLC11Â Â |
NCBI Protein Information: | sodium-coupled neutral amino acid transporter 9 |
UniProt Protein Name: | Sodium-coupled neutral amino acid transporter 9 |
UniProt Synonym Protein Names: | Solute carrier family 38 member 9 |
Protein Family: | Sodium-coupled neutral amino acid transporter |
UniProt Gene Name: | SLC38A9Â Â |
UniProt Entry Name: | S38A9_HUMAN |