The SLC38A9 Polyclonal Antibody (PACO46882) is a valuable tool for researchers studying SLC38A9, a key transporter protein involved in amino acid sensing and mTORC1 signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the SLC38A9 protein, this antibody enables accurate detection and analysis in various cell types, making it essential for studies in metabolism, cell growth, and nutrient sensing.
SLC38A9, a member of the SLC38 transporter family, plays a crucial role in the regulation of cellular amino acid uptake and signaling pathways that control cell growth and metabolism. Its involvement in mTORC1 activation makes it an attractive target for research into diseases like cancer, metabolic disorders, and aging-related conditions. Investigating the function of SLC38A9 is essential for unraveling its role in cellular homeostasis and developing targeted therapies for related pathologies.
Western Blot. Positive WB detected in: Jurkat whole cell lysate. All lanes: SLC38A9 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 64, 53, 57 kDa. Observed band size: 64 kDa..
Immunohistochemistry of paraffin-embedded human liver cancer using PACO46882 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO46882 at dilution of 1:100.
Background:
Lysosomal amino acid, transporter involved in the activation of mTORC1 in response to amino acid,. Probably acts as an amino acid, sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid, sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acid,. Following activation by amino acid, , the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of amino acid, with low capacity and specificity with a slight preference for polar amino acid, , suggesting that it acts as an amino acid, sensor instead. The high concentration of arginine in lysosomes suggests that it acts as an arginine sensor.
Synonyms:
Sodium-coupled neutral amino acid, transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11), SLC38A9, URLC11
UniProt Protein Function:
SLC38A9: Putative sodium-dependent amino acid/proton antiporter. Belongs to the amino acid/polyamine transporter 2 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-passChromosomal Location of Human Ortholog: 5q11.2Cellular Component: endoplasmic reticulum; late endosome; lysosomeMolecular Function: amino acid transmembrane transporter activity; protein bindingBiological Process: positive regulation of TOR signaling pathway
