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SLC36A2 Antibody (PACO36014)

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SKU:
PACO36014
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • SLC36A2 Antibody PACO36014
  • SLC36A2 Antibody PACO36014
  • SLC36A2 Antibody PACO36014
€359

Description

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SLC36A2 Antibody (PACO36014)

The SLC36A2 Polyclonal Antibody (PAC036014) is a valuable tool for researchers studying SLC36A2, a key protein involved in amino acid transport and metabolism. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting.SLC36A2, also known as PAT1, is a member of the proton/amino acid transporter (PAT) family and plays a crucial role in the uptake of amino acids into cells. Its function is essential for cellular growth and metabolism, making it a potential target for therapeutic interventions in diseases related to amino acid dysregulation.

By using the SLC36A2 Polyclonal Antibody, researchers can investigate the expression and localization of SLC36A2 in different cell types and tissues, providing valuable insights into its role in amino acid transport and metabolism. This antibody is ideal for studies in the fields of biochemistry, cell biology, and metabolism research. Unlock the potential of SLC36A2 and advance your research with the SLC36A2 Polyclonal Antibody.

Antibody Name:SLC36A2 Antibody (PACO36014)
Antibody SKU:PACO36014
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Proton-coupled amino acid, transporter 2 protein (1-58AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO36014 at dilution of 1:100.
Product ImageImmunofluorescent analysis of A431 cells using PACO36014 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Product ImageImmunohistochemistry of paraffin-embedded human kidney tissue using PACO36014 at dilution of 1:100.
Background:Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acid,. Transports glycine and proline. Inhibited by sarcosine.
Synonyms:Proton-coupled amino acid, transporter 2 (Proton/amino acid, transporter 2) (Solute carrier family 36 member 2) (Tramdorin-1), SLC36A2, PAT2 TRAMD1
UniProt Protein Function:SLC36A2: Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine. Defects in SLC36A2 are a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. Defects in SLC36A2 are a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Mutations in SLC36A2 that retain residual transport activity result in the IG phenotype only when combined with haploinsufficiency of the imino acid transporter SLC6A20 or deficiency of the neutral amino acid transporter SLC6A19. Additional polymorphisms and mutations in SLC6A18 can contribute to iminoglycinuria in some families. Belongs to the amino acid/polyamine transporter 2 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC familyChromosomal Location of Human Ortholog: 5q33.1Cellular Component: cytoplasm; integral to membrane; plasma membraneMolecular Function: amino acid transmembrane transporter activity; glycine transmembrane transporter activity; hydrogen ion transmembrane transporter activity; hydrogen:amino acid symporter activity; L-alanine transmembrane transporter activity; L-proline transmembrane transporter activityBiological Process: amino acid transport; glycine transport; ion transport; L-alanine transportDisease: Hyperglycinuria; Iminoglycinuria
UniProt Protein Details:
NCBI Summary:This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
UniProt Code:Q495M3
NCBI GenInfo Identifier:222418631
NCBI Gene ID:153201
NCBI Accession:NP_861441
UniProt Secondary Accession:Q495M3,Q495M4, Q495M6, Q6ZWK5, Q7Z6B5
UniProt Related Accession:Q495M3
Molecular Weight:Predicted: 53 kDaObserved: 52 kDa
NCBI Full Name:proton-coupled amino acid transporter 2
NCBI Synonym Full Names:solute carrier family 36 member 2
NCBI Official Symbol:SLC36A2  
NCBI Official Synonym Symbols:PAT2; TRAMD1  
NCBI Protein Information:proton-coupled amino acid transporter 2
UniProt Protein Name:Proton-coupled amino acid transporter 2
UniProt Synonym Protein Names:Solute carrier family 36 member 2; Tramdorin-1
Protein Family:Proton-coupled amino acid transporter
UniProt Gene Name:SLC36A2  
UniProt Entry Name:S36A2_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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