SLC35D2 Antibody (PACO37194)
- SKU:
- PACO37194
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC35D2 Antibody (PACO37194)
The SLC35D2 Polyclonal Antibody (PAC037194) is a valuable tool for researchers studying SLC35D2, a protein involved in nucleotide sugar transport. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the SLC35D2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it essential for investigations in the fields of biochemistry and molecular biology.SLC35D2 is a crucial player in the transport of nucleotide sugars within cells, a process essential for glycosylation and proper protein function.
Dysregulation of SLC35D2 has been linked to various diseases, including congenital disorders of glycosylation and cancer. Research on SLC35D2 is paramount for understanding the mechanisms underlying these conditions and for developing targeted therapies in the future. By using the SLC35D2 Polyclonal Antibody, scientists can further unravel the functions and implications of this important transporter protein.
| Antibody Name: | SLC35D2 Antibody (PACO37194) |
| Antibody SKU: | PACO37194 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter protein (75-146AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO37194 at dilution of 1:100. |
| Background: | Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. |
| Synonyms: | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (Homolog of Fringe connection protein 1) (HFRC1) (SQV7-like protein) (SQV7L) (Solute carrier family 35 member D2) (UDP-galactose transporter-related protein 8) (UGTrel8), SLC35D2, HFRC UGTREL8 |
| UniProt Protein Function: | SLC35D2: Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Belongs to the TPT transporter family. SLC35D subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-passChromosomal Location of Human Ortholog: 9q22.32Cellular Component: Golgi membrane; integral to membraneMolecular Function: nucleotide-sugar transmembrane transporter activityBiological Process: keratan sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; keratan sulfate biosynthetic process; carbohydrate transport; pathogenesis; transmembrane transport |
| UniProt Protein Details: | |
| NCBI Summary: | Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q76EJ3 |
| NCBI GenInfo Identifier: | 223029426 |
| NCBI Gene ID: | 11046 |
| NCBI Accession: | NP_008932 |
| UniProt Secondary Accession: | Q76EJ3,O95454, Q498C1, Q75W21, Q7Z5X5 |
| UniProt Related Accession: | Q76EJ3 |
| Molecular Weight: | 26,702 Da |
| NCBI Full Name: | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter isoform a |
| NCBI Synonym Full Names: | solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 |
| NCBI Official Symbol: | SLC35D2Â Â |
| NCBI Official Synonym Symbols: | hfrc; HFRC1; SQV7L; UGTrel8Â Â |
| NCBI Protein Information: | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; SQV7-like protein; fringe connection; UDP-N-acetylglucosamine transporter; solute carrier family 35, member D2; homolog of Fringe connection protein 1; UDP-galactose transporter-related protein 8 |
| UniProt Protein Name: | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
| UniProt Synonym Protein Names: | Homolog of Fringe connection protein 1; HFRC1; SQV7-like protein; SQV7L; Solute carrier family 35 member D2; UDP-galactose transporter-related protein 8; UGTrel8 |
| Protein Family: | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter |
| UniProt Gene Name: | SLC35D2Â Â |
| UniProt Entry Name: | S35D2_HUMAN |
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