The SLC35C1 Polyclonal Antibody (PACO38686) is a valuable tool for researchers studying the SLC35C1 protein, which plays a key role in nucleotide sugar transport processes within cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SLC35C1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in cell biology and metabolism research.SLC35C1 is a member of the solute carrier family, responsible for transporting nucleotide sugars into the Golgi apparatus for glycosylation processes.
Dysregulation of SLC35C1 function has been linked to various diseases, including metabolic disorders and cancer. The SLC35C1 Polyclonal Antibody provides researchers with a reliable tool for investigating the role of SLC35C1 in these pathological conditions and exploring potential therapeutic targets for intervention. Understanding the mechanisms governing nucleotide sugar transport through SLC35C1 is essential for advancing our knowledge of cellular metabolism and developing new treatments for related diseases.
Antibody Name:
SLC35C1 Antibody (PACO38686)
Antibody SKU:
PACO38686
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human GDP-fucose transporter 1 protein (287-364AA)
IHC image of PACO38686 diluted at 1:400 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Involved in GDP-fucose import from the cytoplasm into the Golgi lumen.
Synonyms:
GDP-fucose transporter 1 (Solute carrier family 35 member C1), SLC35C1, FUCT1
UniProt Protein Function:
SLC35C1: Involved in GDP-fucose import from the cytoplasm into the Golgi lumen. Defects in SLC35C1 are the cause of congenital disorder of glycosylation type 2C (CDG2C); also known as leukocyte adhesion deficiency type II (LAD2). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. The clinical features of CDG2C include mental retardation, short stature, facial stigmata, and recurrent bacterial peripheral infections with persistently elevated peripheral leukocytes. Biochemically, CDG2C is characterized by a lack of fucosylated glycoconjugates, including selectin ligands. Belongs to the TPT transporter family. SLC35C subfamily.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 11p11.2Cellular Component: Golgi membrane; Golgi apparatus; integral to membraneBiological Process: carbohydrate transport; lipid glycosylation; negative regulation of Notch signaling pathway; transmembrane transportDisease: Congenital Disorder Of Glycosylation, Type Iic
UniProt Protein Details:
NCBI Summary:
This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
