The SLC34A2 Polyclonal Antibody (CAB9460) is designed for research involving SLC34A2, a cell surface phosphate transporter involved in phosphate homeostasis and lung diseases. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in Western blot and immunohistochemistry applications. It binds specifically to the SLC34A2 protein, allowing for the detection and analysis of its expression in various cell types and tissues.SLC34A2, also known as sodium-dependent phosphate transporter 2A, plays a crucial role in phosphate uptake and maintenance of phosphate levels in the body. Dysregulation of SLC34A2 has been linked to lung diseases such as pulmonary alveolar microlithiasis and pulmonary fibrosis.
Research into the function and regulation of SLC34A2 is important for understanding its role in these diseases and for developing targeted therapies.By utilizing the SLC34A2 Polyclonal Antibody, researchers can gain valuable insights into the expression and localization of SLC34A2 in different cell types and tissues, furthering our understanding of its physiological functions and potential implications in disease pathology. This antibody is a valuable tool for studies in lung biology, phosphate metabolism, and related fields.
Product Name:
SLC34A2 Rabbit Polyclonal Antibody
SKU:
CAB9460
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 234-362 of human SLC34A2 (NP_001171469.1).
A-549,293T,HT-29,MCF7,Mouse small intestine,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
Membrane, Multi-pass membrane protein.
Calculated MW:
76kDa
Observed MW:
76kDa
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10568
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC34A2 Rabbit pAb (CAB9460) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
