SLC33A1 Antibody (PACO49122)
- SKU:
- PACO49122
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC33A1 Antibody (PACO49122)
The SLC33A1 Antibody (PAC049122) is a polyclonal antibody specifically designed for research involving the SLC33A1 protein, also known as Acetyl-CoA transporter 1. This membrane protein is involved in the transport of acetyl-CoA into the lumen of the Golgi apparatus, playing a key role in the acetylation of glycoproteins.Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the SLC33A1 protein, researchers can easily detect and analyze its expression in various cell types, making it an ideal tool for studies in biochemistry, cell biology, and neuroscience.The SLC33A1 protein is essential for the acetylation of glycoproteins, which is crucial for proper protein folding and trafficking within the cell.
Dysregulation of SLC33A1 has been linked to neurodegenerative diseases, lysosomal storage disorders, and metabolic syndromes. By studying the function and expression of SLC33A1, researchers can gain insights into these diseases and potentially develop targeted therapies to treat them.Overall, the SLC33A1 Antibody (PAC049122) is a valuable tool for researchers studying the role of the SLC33A1 protein in various biological processes and disease states. Its specificity and reliability make it an essential component of any research project looking to unravel the intricacies of cellular
| Antibody Name: | SLC33A1 Antibody (PACO49122) |
| Antibody SKU: | PACO49122 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Acetyl-coenzyme A transporter 1 protein (1-74AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO49122 at dilution of 1:100. |
 | Western Blot. Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Mouse brain tissue. All lanes: SLC33A1 antibody at 2.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 61 kDa. Observed band size: 50 kDa. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO49122 at dilution of 1:100. |
| Background: | Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling. |
| Synonyms: | Acetyl-coenzyme A transporter 1 (AT-1) (Acetyl-CoA transporter 1) (Solute carrier family 33 member 1), SLC33A1, ACATN AT1 |
| UniProt Protein Function: | SLC33A1: Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides. Defects in SLC33A1 are the cause of spastic paraplegia autosomal dominant type 42 (SPG42). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Defects in SLC33A1 are the cause of congenital cataracts, hearing loss, and neurodegeneration (CCHLND). CCHLND is an autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination. Belongs to the SLC33A transporter family. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter Chromosomal Location of Human Ortholog: 3q25.31 Cellular Component: Golgi membrane; endoplasmic reticulum membrane; membrane; integral to plasma membrane Molecular Function:acetyl-CoA transporter activity; solute:hydrogen symporter activity Biological Process: proton transport; acetyl-CoA transport; transport; transmembrane transport Disease: Spastic Paraplegia 42, Autosomal Dominant; Congenital Cataracts, Hearing Loss, And Neurodegeneration |
| NCBI Summary: | The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010] |
| UniProt Code: | O00400 |
| NCBI GenInfo Identifier: | 74735319 |
| NCBI Gene ID: | 9197 |
| NCBI Accession: | O00400.1 |
| UniProt Secondary Accession: | O00400,B2R5Q2, D3DNK4, |
| UniProt Related Accession: | O00400 |
| Molecular Weight: | 549 |
| NCBI Full Name: | Acetyl-coenzyme A transporter 1 |
| NCBI Synonym Full Names: | solute carrier family 33 (acetyl-CoA transporter), member 1 |
| NCBI Official Symbol: | SLC33A1Â Â |
| NCBI Official Synonym Symbols: | AT1; AT-1; ACATN; SPG42; CCHLNDÂ Â |
| NCBI Protein Information: | acetyl-coenzyme A transporter 1 |
| UniProt Protein Name: | Acetyl-coenzyme A transporter 1 |
| UniProt Synonym Protein Names: | Solute carrier family 33 member 1 |
| Protein Family: | Acetyl-coenzyme A transporter |
| UniProt Gene Name: | SLC33A1Â Â |
| UniProt Entry Name: | ACATN_HUMAN |
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