The SLC30A10 Polyclonal Antibody (PAC04666) is a valuable tool for researchers investigating the SLC30A10 protein, which is known to be a member of the SLC30 family of zinc transporters. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it an ideal choice for experiments involving Western blot analyses.SLC30A10 plays a crucial role in cellular zinc homeostasis and is essential for the proper functioning of various biological processes. Studies have suggested its involvement in zinc transport across cellular membranes and its potential role in zinc-related diseases.
By using this antibody, researchers can detect and analyze SLC30A10 protein expression in a variety of cell types, enabling further exploration of its function in physiology and pathophysiology.Overall, the SLC30A10 Polyclonal Antibody offers a reliable tool for investigating the role of SLC30A10 in zinc transport and related cellular processes. Its application in research may contribute to a better understanding of zinc homeostasis and its implications for human health and disease.
Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: SLC30A10 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 53, 27, 25 kDa. Observed band size: 53 kDa..
Immunofluorescent analysis of HepG2 cells using PACO46666 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human spleen tissue using PACO46666 at dilution of 1:100.
Background:
Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.
Synonyms:
Zinc transporter 10 (ZnT-10) (Manganese transporter SLC30A10) (Solute carrier family 30 member 10), SLC30A10, ZNT10 ZNT8
UniProt Protein Function:
SLC30A10: May be involved in zinc transport out of the cell, being a zinc-efflux transporter. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 1q41Cellular Component: plasma membraneMolecular Function: zinc ion transmembrane transporter activityBiological Process: manganese ion transport; response to zinc ionDisease: Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis
UniProt Protein Details:
NCBI Summary:
This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]
