Anti-SLC2A5 Antibody (CAB13650)
- SKU:
- CAB13650
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Anti-SLC2A5 Antibody (CAB13650)
The SLC2A5 Polyclonal Antibody (CAB13650) is a powerful tool for researchers studying SLC2A5, a glucose transporter protein involved in glucose uptake. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SLC2A5 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in metabolism, diabetes, and cancer research.SLC2A5, also known as GLUT5, plays a crucial role in the transport of fructose across cell membranes, particularly in the intestine and kidney.
Dysregulation of SLC2A5 has been implicated in various metabolic disorders, highlighting its importance as a potential therapeutic target. By studying the function and expression of SLC2A5, researchers can gain valuable insights into the mechanisms underlying glucose metabolism and its implications for human health. This antibody is a valuable tool for advancing our understanding of SLC2A5 and its impact on metabolic processes.
| Antibody Name: | Anti-SLC2A5 Antibody |
| Antibody SKU: | CAB13650 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC2A5 (NP_003030.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | Mouse testis, Mouse kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC2A5 (NP_003030.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MEQQ DQSM KEGR LTLV LALA TLIA AFGS SFQY GYNV AAVN SPAL LMQQ FYNE TYYG RTGE FMED FPLT LLWS VTVS MFPF GGFI GSLL VGPL VNKF GRKG |
| Gene ID: | 6518 |
| Uniprot: | P22732 |
| Cellular Location: | Apical cell membrane, Membrane, Multi-pass membrane protein |
| Calculated MW: | 26kDa/54kDa |
| Observed MW: | 65kDa |
| Synonyms: | SLC2A5, GLUT-5, GLUT5 |
| Background: | The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. |
| UniProt Protein Function: | GLUT5: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Plays an important role in fructose absorption by the intestine. Expressed primarily in the jejunal region of the small intestine. Expressed at low levels in human kidney, skeletal muscle, adipocytes, microglial cells and in the human blood-brain barrier. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36.2 Cellular Component: apical plasma membrane; integral to plasma membrane; plasma membrane; sarcolemma Molecular Function:fructose transmembrane transporter activity; glucose transmembrane transporter activity Biological Process: carbohydrate metabolic process; fructose transport; glucose transport; hexose transport; regulation of systemic arterial blood pressure mediated by a chemical signal; response to fructose stimulus |
| UniProt Code: | P22732 |
| NCBI GenInfo Identifier: | 121764 |
| NCBI Gene ID: | 6518 |
| NCBI Accession: | P22732.1 |
| UniProt Secondary Accession: | P22732,Q14770, Q5T977, Q8IVB3, |
| UniProt Related Accession: | P22732 |
| Molecular Weight: | 26,519 Da |
| NCBI Full Name: | Solute carrier family 2, facilitated glucose transporter member 5 |
| NCBI Synonym Full Names: | solute carrier family 2 member 5 |
| NCBI Official Symbol: | SLC2A5Â Â |
| NCBI Official Synonym Symbols: | GLUT5; GLUT-5Â Â |
| NCBI Protein Information: | solute carrier family 2, facilitated glucose transporter member 5 |
| UniProt Protein Name: | Solute carrier family 2, facilitated glucose transporter member 5 |
| UniProt Synonym Protein Names: | Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 |
| UniProt Gene Name: | SLC2A5Â Â |
| UniProt Entry Name: | GTR5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC2A5 antibody (CAB13650) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 20s. |
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