The SLC2A4 Polyclonal Antibody (CAB7637) is a versatile tool for researchers studying SLC2A4, a glucose transporter protein involved in glucose homeostasis and insulin signaling. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the SLC2A4 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in metabolism, diabetes, and related disorders.
SLC2A4, also known as GLUT4, is a pivotal player in glucose uptake and utilization in insulin-responsive tissues such as muscle and adipose tissue. Dysregulation of SLC2A4 function is implicated in insulin resistance, a hallmark of type 2 diabetes and metabolic syndrome. Investigating the role of SLC2A4 can provide valuable insights into the molecular mechanisms underlying these conditions and aid in the development of novel therapeutic strategies aimed at improving glucose metabolism and insulin sensitivity.
Product Name:
GLUT4 Rabbit Polyclonal Antibody
SKU:
CAB7637
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 450-509 of human GLUT4 (NP_001033.1).
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM).
Purification Method:
Affinity purification
Gene ID:
6517
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GLUT4 Rabbit pAb (CAB7637) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
