Anti-SLC2A2 Antibody (CAB9843)
- SKU:
- CAB9843
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Description
Anti-SLC2A2 Antibody (CAB9843)
The SLC2A2 Polyclonal Antibody (CAB9843) is specifically developed for research involving SLC2A2, a cell membrane glucose transporter protein that plays a crucial role in glucose uptake in various tissues, including the liver, kidney, and small intestine. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in applications such as Western blotting.SLC2A2, also known as GLUT2, is essential for glucose homeostasis and is involved in glucose sensing and uptake in insulin-producing pancreatic beta cells.
Dysregulation of SLC2A2 has been associated with diabetes and metabolic disorders, making it an important target for research in these fields. By detecting and analyzing SLC2A2 expression, researchers can further understand its role in glucose metabolism and potentially develop novel therapies for related conditions.The SLC2A2 Polyclonal Antibody (CAB9843) is a valuable tool for immunology and diabetes research, providing insights into the function and regulation of SLC2A2 in various physiological and pathological contexts.
| Antibody Name: | Anti-SLC2A2 Antibody |
| Antibody SKU: | CAB9843 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC2A2 (NP_000331.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SW480, THP-1, Mouse liver, Mouse kidney, Rat liver |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SLC2A2 (NP_000331.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MTED KVTG TLVF TVIT AVLG SFQF GYDI GVIN APQQ VIIS HYRH VLGV PLDD RKAI NNYV INST DELP TISY SMNP KPTP WAEE ETVA AAQL ITML WSLS |
| Gene ID: | 6514 |
| Uniprot: | P11168 |
| Cellular Location: | Membrane, Multi-pass membrane protein |
| Calculated MW: | 44kDa/57kDa |
| Observed MW: | 57kDa |
| Synonyms: | SLC2A2, GLUT2 |
| Background: | This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. |
| UniProt Protein Function: | GLUT2: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q26.1-q26.2 Cellular Component: membrane; integral to plasma membrane; cytoplasm; plasma membrane; brush border Molecular Function:D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity Biological Process: hexose transport; carbohydrate metabolic process; energy reserve metabolic process; pathogenesis; glucose transport; endocrine pancreas development; transmembrane transport; regulation of insulin secretion Disease: Fanconi-bickel Syndrome; Diabetes Mellitus, Noninsulin-dependent |
| NCBI Summary: | This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] |
| UniProt Code: | P11168 |
| NCBI GenInfo Identifier: | 121756 |
| NCBI Gene ID: | 6514 |
| NCBI Accession: | P11168.1 |
| UniProt Secondary Accession: | P11168,Q9UCW9, A8K481, B2R936, B7Z547, F8W8V8, |
| UniProt Related Accession: | P11168 |
| Molecular Weight: | 44,702 Da |
| NCBI Full Name: | Solute carrier family 2, facilitated glucose transporter member 2 |
| NCBI Synonym Full Names: | solute carrier family 2 (facilitated glucose transporter), member 2 |
| NCBI Official Symbol: | SLC2A2Â Â |
| NCBI Official Synonym Symbols: | GLUT2Â Â |
| NCBI Protein Information: | solute carrier family 2, facilitated glucose transporter member 2; glucose transporter type 2, liver |
| UniProt Protein Name: | Solute carrier family 2, facilitated glucose transporter member 2 |
| UniProt Synonym Protein Names: | Glucose transporter type 2, liver; GLUT-2 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC2A2Â Â |
| UniProt Entry Name: | GTR2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SLC2A2 antibody (CAB9843) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using SLC2A2 antibody (CAB9843) at dilution of 1:100 (40x lens). |
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