The SLC29A3 Polyclonal Antibody (CAB10377) is a valuable tool for researchers studying SLC29A3, a transporter protein involved in cellular uptake of nucleosides and nucleobases. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the SLC29A3 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential component for studies in molecular biology and pharmacology.SLC29A3, also known as hENT3, plays a crucial role in nucleoside and nucleobase transport, which is essential for processes such as DNA replication and RNA synthesis.
Dysregulation of SLC29A3 has been linked to various diseases, including cancer and genetic disorders affecting nucleoside metabolism. By studying the function and regulation of SLC29A3, researchers can gain insight into potential therapeutic targets for these diseases and develop strategies for personalized medicine approaches. The SLC29A3 Polyclonal Antibody is a key resource for advancing research in this important field.
Product Name:
SLC29A3 Rabbit Polyclonal Antibody
SKU:
CAB10377
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human SLC29A3 (NP_060814.4).
Late endosome membrane, Lysosome membrane, Membrane, Multi-pass membrane protein.
Calculated MW:
52kDa
Observed MW:
50kDa
This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
55315
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SLC29A3 antibody (CAB10377) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
