The SLC29A1 Polyclonal Antibody (CAB13205) is a specialized research tool designed for studying SLC29A1, a key protein involved in nucleoside transport. This antibody, raised in rabbits, is specifically designed for use with human samples and has been validated for Western blot applications. By binding to the SLC29A1 protein, researchers can effectively detect and analyze its expression in various cell types, making it an essential tool for studies in molecular biology and drug development.SLC29A1, also known as equilibrative nucleoside transporter 1 (ENT1), serves a crucial role in cellular uptake of nucleosides, which are essential for DNA and RNA synthesis. Understanding the function of SLC29A1 is vital for unraveling its involvement in various physiological processes, including nucleotide metabolism, neurotransmission, and antiviral responses.
By targeting SLC29A1, researchers can gain valuable insights into its role in diseases such as cancer, neurological disorders, and viral infections, paving the way for the development of novel therapeutic interventions targeting nucleoside transport mechanisms.Overall, the SLC29A1 Polyclonal Antibody provides a valuable tool for investigating the role of SLC29A1 in health and disease, offering a pathway for further exploration and discovery in the field of nucleoside transport biology.
Product Name:
SLC29A1 Rabbit Polyclonal Antibody
SKU:
CAB13205
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SLC29A1 (NP_001071645.1).
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2030
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from rat lung, using SLC29A1 Rabbit pAb (CAB13205) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
