SLC28A1 Antibody (PACO29940)
- SKU:
- PACO29940
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
SLC28A1 Antibody (PACO29940)
The SLC28A1 Antibody (PAC029940) is a valuable tool for researchers studying SLC28A1, a vital member of the solute carrier family. This polyclonal antibody, raised in rabbits, demonstrates high specificity and sensitivity for human samples, making it suitable for various research applications. It is validated for use in Western blot analysis, enabling accurate detection and analysis of the SLC28A1 protein in different cell types.SLC28A1, also known as concentrative nucleoside transporter 1 (CNT1), plays a crucial role in the transport of nucleosides across cell membranes, impacting processes like nucleic acid metabolism and nucleoside-based drug uptake.
Its involvement in these mechanisms implicates SLC28A1 in various physiological and pathological conditions, making it a promising target for research in areas such as cancer and infectious diseases. Understanding the function and regulation of SLC28A1 could reveal insights into novel therapeutic strategies for these complex health issues.
| Antibody Name: | SLC28A1 Antibody (PACO29940) |
| Antibody SKU: | PACO29940 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Sodium/nucleoside cotransporter 1 protein (1-80AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO29940 at dilution of 1:100. |
 | Immunofluorescent analysis of Hela cells using PACO29940 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO29940 at dilution of 1:100. |
| Background: | Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine. |
| Synonyms: | Sodium/nucleoside cotransporter 1 (Concentrative nucleoside transporter 1) (CNT 1) (hCNT1) (Na(+)/nucleoside cotransporter 1) (Sodium-coupled nucleoside transporter 1) (Solute carrier family 28 member 1), SLC28A1, CNT1 |
| UniProt Protein Function: | SLC28A1: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine. Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 15q25.3Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: nucleoside transmembrane transporter activity; nucleoside:sodium symporter activity; pyrimidine- and adenine-specific:sodium symporter activityBiological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleoside transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O00337 |
| NCBI GenInfo Identifier: | 229462744 |
| NCBI Gene ID: | 9154 |
| NCBI Accession: | O00337.2 |
| UniProt Secondary Accession: | O00337,O00335, O00336, Q5U5S6, Q5U648, Q9UEZ9, A0AV42 A8K7I2 |
| UniProt Related Accession: | O00337 |
| Molecular Weight: | 20,180 Da |
| NCBI Full Name: | Sodium/nucleoside cotransporter 1 |
| NCBI Synonym Full Names: | solute carrier family 28 member 1 |
| NCBI Official Symbol: | SLC28A1Â Â |
| NCBI Official Synonym Symbols: | CNT1; HCNT1Â Â |
| NCBI Protein Information: | sodium/nucleoside cotransporter 1 |
| UniProt Protein Name: | Sodium/nucleoside cotransporter 1 |
| UniProt Synonym Protein Names: | Concentrative nucleoside transporter 1; CNT 1; hCNT1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 |
| Protein Family: | Sodium/nucleoside cotransporter |
| UniProt Gene Name: | SLC28A1Â Â |
| UniProt Entry Name: | S28A1_HUMAN |
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