| UniProt Protein Function: | SLC28A1: Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine. Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 15q25.3Cellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: nucleoside transmembrane transporter activity; nucleoside:sodium symporter activity; pyrimidine- and adenine-specific:sodium symporter activityBiological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; nucleoside transport |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O00337 |
| NCBI GenInfo Identifier: | 229462744 |
| NCBI Gene ID: | 9154 |
| NCBI Accession: | O00337.2 |
| UniProt Secondary Accession: | O00337,O00335, O00336, Q5U5S6, Q5U648, Q9UEZ9, A0AV42 A8K7I2 |
| UniProt Related Accession: | O00337 |
| Molecular Weight: | 20,180 Da |
| NCBI Full Name: | Sodium/nucleoside cotransporter 1 |
| NCBI Synonym Full Names: | solute carrier family 28 member 1 |
| NCBI Official Symbol: | SLC28A1Â Â |
| NCBI Official Synonym Symbols: | CNT1; HCNT1Â Â |
| NCBI Protein Information: | sodium/nucleoside cotransporter 1 |
| UniProt Protein Name: | Sodium/nucleoside cotransporter 1 |
| UniProt Synonym Protein Names: | Concentrative nucleoside transporter 1; CNT 1; hCNT1; Na(+)/nucleoside cotransporter 1; Sodium-coupled nucleoside transporter 1; Solute carrier family 28 member 1 |
| Protein Family: | Sodium/nucleoside cotransporter |
| UniProt Gene Name: | SLC28A1Â Â |
| UniProt Entry Name: | S28A1_HUMAN |
