SLC27A5 Antibody (PACO23797)
- SKU:
- PACO23797
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC27A5 Antibody (PACO23797)
The SLC27A5 Antibody (PAC023797) is a key tool for researchers studying SLC27A5, a protein involved in lipid metabolism and fatty acid uptake in cells. This polyclonal antibody, raised in rabbits, is highly specific to human SLC27A5 and is validated for use in Western blot and immunohistochemistry applications.SLC27A5, also known as very-long-chain acyl-CoA synthetase, plays a critical role in lipid biosynthesis and energy metabolism. Dysregulation of SLC27A5 has been implicated in various metabolic disorders, making it an important target for research in obesity, diabetes, and fatty liver disease.
The SLC27A5 Antibody enables precise detection and analysis of SLC27A5 protein levels in different cell types, providing valuable insights into lipid homeostasis and metabolic pathways.By understanding the function and regulation of SLC27A5, researchers can uncover new therapeutic targets for metabolic diseases and develop strategies for managing lipid-related conditions. This antibody is a valuable tool for advancing research in lipid metabolism and exploring the potential of SLC27A5 as a therapeutic target in metabolic disorders.
| Antibody Name: | SLC27A5 Antibody (PACO23797) |
| Antibody SKU: | PACO23797 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human SLC27A5. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HepG2 cells, using SLC27A5 antibody. |
 | Immunofluorescence analysis of A549 cells, using SLC27A5 antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using SLC27A5 antibody. |
| Background: | Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. |
| Synonyms: | EC 6.2.1.7; FACVL3; FATP5; MGC143799; S27A5 |
| UniProt Protein Function: | SLC27A5: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Belongs to the ATP-dependent AMP-binding enzyme family.Protein type: EC 6.2.1.7; Membrane protein, multi-pass; Endoplasmic reticulum; Ligase; Membrane protein, integral; Lipid Metabolism - primary bile acid biosynthesisChromosomal Location of Human Ortholog: 19q13.43Cellular Component: basal plasma membrane; endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; protein complexMolecular Function: ATP binding; cholate-CoA ligase activity; fatty acid transporter activity; long-chain-fatty-acid-CoA ligase activity; protein complex binding; very-long-chain-fatty-acid-CoA ligase activityBiological Process: bile acid and bile salt transport; bile acid biosynthetic process; bile acid metabolic process; ketone body biosynthetic process; long-chain fatty acid metabolic process; plasma membrane long-chain fatty acid transport; triacylglycerol mobilization; very-long-chain fatty acid metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y2P5 |
| NCBI GenInfo Identifier: | 13325057 |
| NCBI Gene ID: | 10998 |
| NCBI Accession: | NP_036386.1 |
| UniProt Secondary Accession: | Q9Y2P5,B3KVP6, B4DPQ1 |
| UniProt Related Accession: | Q9Y2P5 |
| Molecular Weight: | 66,846 Da |
| NCBI Full Name: | bile acyl-CoA synthetase |
| NCBI Synonym Full Names: | solute carrier family 27 (fatty acid transporter), member 5 |
| NCBI Official Symbol: | SLC27A5Â Â |
| NCBI Official Synonym Symbols: | BAL; ACSB; BACS; FATP5; ACSVL6; FACVL3; FATP-5; VLACSR; VLCSH2; VLCS-H2Â Â |
| NCBI Protein Information: | bile acyl-CoA synthetase |
| UniProt Protein Name: | Bile acyl-CoA synthetase |
| UniProt Synonym Protein Names: | Bile acid-CoA ligase; BA-CoA ligase; BAL; Cholate--CoA ligase; Fatty acid transport protein 5; FATP-5; Fatty-acid-coenzyme A ligase, very long-chain 3; Solute carrier family 27 member 5; Very long-chain acyl-CoA synthetase homolog 2; VLCS-H2; VLCSH2; Very long-chain acyl-CoA synthetase-related protein; VLACS-related; VLACSR |
| Protein Family: | Very long-chain acyl-CoA synthetase |
| UniProt Gene Name: | SLC27A5Â Â |
| UniProt Entry Name: | S27A5_HUMAN |
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