The SLC27A5 Polyclonal Antibody (PACO02384) is a valuable tool for researchers studying SLC27A5, a protein involved in lipid metabolism and fatty acid transport. This antibody, generated in rabbits, is specifically designed to target SLC27A5 in human samples and is validated for use in Western blot applications. By binding to the SLC27A5 protein, this antibody allows for the detection and analysis of SLC27A5 expression in various cell types, making it ideal for research in metabolism, obesity, and related disorders.SLC27A5, also known as fatty acid transport protein 5 (FATP5), plays a crucial role in fatty acid uptake and utilization in cells.
Dysregulation of SLC27A5 has been linked to metabolic disorders such as obesity, diabetes, and cardiovascular disease. Research on SLC27A5 can provide insights into the mechanisms of lipid metabolism and offer potential targets for therapeutic interventions in metabolic diseases.Overall, the SLC27A5 Polyclonal Antibody (PACO02384) offers a valuable tool for researchers interested in studying the role of SLC27A5 in metabolism and related disorders. Its high specificity and reactivity make it a reliable choice for Western blot experiments and further exploration of SLC27A5 function in various biological contexts.
Antibody Name:
SLC27A5 Antibody
Antibody SKU:
PACO02384
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC, IF
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human ACSVL6.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
SLC27A5; ACSB; ACSVL6; FACVL3; FATP5; Bile acyl-CoA synthetase; BACS; Bile acid-CoA ligase; BA-CoA ligase; BAL; Cholate--CoA ligase; Fatty acid transport protein 5; FATP-5; Fatty-acid-coenzyme A ligase; very long-chain 3; Solute carrier fam
UniProt Protein Function:
SLC27A5: Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Belongs to the ATP-dependent AMP-binding enzyme family.Protein type: EC 6.2.1.7; Membrane protein, multi-pass; Endoplasmic reticulum; Ligase; Membrane protein, integral; Lipid Metabolism - primary bile acid biosynthesisChromosomal Location of Human Ortholog: 19q13.43Cellular Component: basal plasma membrane; endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; protein complexMolecular Function: ATP binding; cholate-CoA ligase activity; fatty acid transporter activity; long-chain-fatty-acid-CoA ligase activity; protein complex binding; very-long-chain-fatty-acid-CoA ligase activityBiological Process: bile acid and bile salt transport; bile acid biosynthetic process; bile acid metabolic process; ketone body biosynthetic process; long-chain fatty acid metabolic process; plasma membrane long-chain fatty acid transport; triacylglycerol mobilization; very-long-chain fatty acid metabolic process
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]
Bile acid-CoA ligase; BA-CoA ligase; BAL; Cholate--CoA ligase; Fatty acid transport protein 5; FATP-5; Fatty-acid-coenzyme A ligase, very long-chain 3; Solute carrier family 27 member 5; Very long-chain acyl-CoA synthetase homolog 2; VLCS-H2; VLCSH2; Very long-chain acyl-CoA synthetase-related protein; VLACS-related; VLACSR
