The SLC26A8 Polyclonal Antibody (PACO39890) is a valuable tool for researchers studying the SLC26A8 protein, a member of the solute carrier family involved in transporting ions and nutrients across cell membranes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.SLC26A8 is known to play a role in renal and male reproductive physiology, making it a promising target for studies related to kidney function, male fertility, and ion transport mechanisms. By binding specifically to the SLC26A8 protein, this antibody enables accurate detection and analysis in various cell types, facilitating research in areas such as nephrology, reproductive health, and molecular biology.
This antibody's ability to target SLC26A8 opens up new possibilities for understanding the physiological functions and pathological implications of this protein. Researchers investigating conditions such as renal disorders, infertility, and ion transport disorders will benefit greatly from the use of the SLC26A8 Polyclonal Antibody in their experiments.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO39890 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO39890 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO39890 at dilution of 1:100.
Background:
Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.
Synonyms:
Testis anion transporter 1 (Anion exchange transporter) (Solute carrier family 26 member 8), SLC26A8, TAT1
UniProt Protein Function:
Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a moleculer complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the SLC26 gene family of anion transporters. Family members are well conserved in gene structure and protein length yet have markedly different tissue expression patterns. The expression of this gene appears to be restricted to spermatocytes. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2010]
