The SLC26A6 Polyclonal Antibody (PACO20498) is a valuable tool for researchers studying SLC26A6, a transmembrane protein involved in ion transport and pH regulation in various tissues, including the kidneys and gastrointestinal tract. This antibody, produced in rabbits, exhibits high specificity and sensitivity when detecting SLC26A6 in human samples, making it ideal for applications such as Western blot and immunohistochemistry.SLC26A6 plays a crucial role in maintaining ion balance and pH homeostasis in the body, making it a key player in various physiological processes.
Dysregulation of SLC26A6 has been linked to disorders such as kidney stones, inflammatory bowel disease, and cystic fibrosis. By studying the expression and function of SLC26A6 using this antibody, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets.This SLC26A6 Polyclonal Antibody is a valuable tool for investigating the role of SLC26A6 in health and disease, making it a valuable addition to any research laboratory focused on ion transport, pH regulation, and related physiological processes.
Antibody Name:
SLC26A6 Antibody (PACO20498)
Antibody SKU:
PACO20498
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SLC26A6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20498(SLC26A6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms:
solute carrier family 26 (anion exchanger), member 6
UniProt Protein Function:
SLC26A6: Does not seem to be involved in anion transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: apical plasma membrane; basolateral plasma membrane; brush border membrane; integral to membrane; integral to plasma membrane; membrane; plasma membrane; vesicle; vesicle membrane
Biological Process: bicarbonate transport; chloride transport; epithelial fluid transport; formate transport; intestinal absorption; intracellular pH elevation; ion transport; mannitol transport; oxalate transport; oxalic acid secretion; regulation of intracellular pH; regulation of membrane potential; sperm capacitation; sulfate transport; transepithelial chloride transport
NCBI Summary:
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]
