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SLC26A5 Antibody (PACO20497)

SKU:
PACO20497
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339

Description

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SLC26A5 Antibody (PACO20497)

The SLC26A5 Antibody (PAC020497) is an essential tool for researchers studying SLC26A5, a protein involved in ion transport and hearing. This polyclonal antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the SLC26A5 protein, this antibody enables the detection and analysis of SLC26A5 in various cell types, making it ideal for studies in auditory biology and ion transport mechanisms.SLC26A5, also known as prestin, is a key player in the functioning of outer hair cells in the cochlea, contributing to the amplification of sound signals.

Mutations in the SLC26A5 gene have been associated with hearing loss and other auditory disorders. By studying the expression and function of SLC26A5, researchers can gain valuable insights into the mechanisms underlying hearing and develop potential therapies for hearing-related conditions. The SLC26A5 Antibody is a valuable tool for advancing our understanding of auditory biology and the role of ion transport in hearing.

Antibody Name:SLC26A5 Antibody (PACO20497)
Antibody SKU:PACO20497
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthetic peptide of human SLC26A5
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20497(SLC26A5 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length.
Synonyms:solute carrier family 26 (anion exchanger), member 5
UniProt Protein Function:Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site ().
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
UniProt Code:P58743
NCBI GenInfo Identifier:269784651
NCBI Gene ID:375611
NCBI Accession:NP_001161434.1
UniProt Secondary Accession:P58743,Q496J2, Q7Z7F3, Q86UF8, Q86UF9, Q86UG0
UniProt Related Accession:P58743
Molecular Weight:81 kDa
NCBI Full Name:prestin isoform e
NCBI Synonym Full Names:solute carrier family 26 member 5
NCBI Official Symbol:SLC26A5  
NCBI Official Synonym Symbols:PRES; DFNB61  
NCBI Protein Information:prestin
UniProt Protein Name:Prestin
UniProt Synonym Protein Names:Solute carrier family 26 member 5
Protein Family:Prestin
UniProt Gene Name:SLC26A5  
UniProt Entry Name:
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