The SLC25A36 Polyclonal Antibody (PACO39810) is a valuable tool for researchers studying the SLC25A36 protein, which plays a critical role in cellular metabolism and energy production. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SLC25A36 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential component for studies in cellular biology and metabolic research.SLC25A36 is a mitochondrial carrier protein involved in the transport of metabolites across the inner mitochondrial membrane, which is essential for proper cellular function and energy production.
Dysregulation of SLC25A36 has been linked to metabolic disorders, neurodegenerative diseases, and cancer, making it a promising target for therapeutic interventions. Understanding the function and regulation of SLC25A36 is crucial for developing treatments that target mitochondrial dysfunction and metabolic imbalance in these disease contexts.Overall, the SLC25A36 Polyclonal Antibody provides researchers with a powerful tool for investigating the role of SLC25A36 in cellular metabolism and its potential implications in various diseases. Its high specificity and reactivity make it an essential asset for studies aiming to uncover the mechanisms underlying metabolic disorders and develop targeted therapies for related conditions.
Western blot. All lanes: SLC25A36 antibody at 4µg/ml. Lane 1: A431 whole cell lysate. Lane 2: A549 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 35, 15, 18 kDa. Observed band size: 35 kDa.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39810 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO39810 at dilution of 1:100.
Background:
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration.
Synonyms:
Solute carrier family 25 member 36, SLC25A36
UniProt Protein Function:
SLC25A36: Belongs to the mitochondrial carrier family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Mitochondrial; Transporter, SLC family; Membrane protein, integral; TransporterChromosomal Location of Human Ortholog: 3q23Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrionMolecular Function: pyrimidine nucleotide transmembrane transporter activity; structural constituent of ribosomeBiological Process: mitochondrial genome maintenance; mitochondrion organization and biogenesis; pyrimidine nucleotide transport; regulation of mitochondrial membrane potential; translation; transmembrane transport
