The SLC25A33 Polyclonal Antibody (PAC041238) is a vital tool for researchers studying SLC25A33, a mitochondrial carrier protein involved in the transport of ATP and phosphate ions across the inner mitochondrial membrane. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the SLC25A33 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for investigations in cell biology and metabolism research.SLC25A33 is a key player in mitochondrial energy metabolism, playing a crucial role in ATP production and maintaining cellular homeostasis.
Dysregulation of SLC25A33 has been implicated in various metabolic disorders and diseases, making it a promising target for therapeutic interventions. Understanding the function and regulation of SLC25A33 is essential for developing strategies to address mitochondrial dysfunction and metabolic disorders effectively.Overall, the SLC25A33 Polyclonal Antibody (PAC041238) offers researchers a reliable and specific tool for studying the role of SLC25A33 in mitochondrial function and metabolic processes, paving the way for advancements in the field of bioenergetics and metabolic disease research.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO41238 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO41238 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO41238 at dilution of 1:100.
Background:
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation.
Synonyms:
Solute carrier family 25 member 33 (Bone marrow stromal cell mitochondrial carrier protein) (BMSC-MCP) (HuBMSC-MCP) (Protein PNC1), SLC25A33
UniProt Protein Function:
SLC25A33: Probable mitochondrial transporter which participates in dendritic cell endocytosis. May associate with mitochondrial oxidative phosphorylation. Belongs to the mitochondrial carrier family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p36.22Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrial membraneMolecular Function: pyrimidine nucleotide transmembrane transporter activity; structural constituent of ribosomeBiological Process: cellular response to insulin stimulus; mitochondrial DNA replication; mitochondrial genome maintenance; mitochondrial signaling pathway; mitochondrion organization and biogenesis; positive regulation of cell growth; positive regulation of cell proliferation; pyrimidine nucleotide transport; regulation of mitochondrial membrane potential; regulation of oxidative phosphorylation; transcription from mitochondrial promoter; translation
UniProt Protein Details:
NCBI Summary:
SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008]
