| Background: | Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration. Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production. Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation. |
| Synonyms: | Solute carrier family 25 member 33 (Bone marrow stromal cell mitochondrial carrier protein) (BMSC-MCP) (HuBMSC-MCP) (Protein PNC1), SLC25A33 |
| UniProt Protein Function: | SLC25A33: Probable mitochondrial transporter which participates in dendritic cell endocytosis. May associate with mitochondrial oxidative phosphorylation. Belongs to the mitochondrial carrier family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p36.22Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrial membraneMolecular Function: pyrimidine nucleotide transmembrane transporter activity; structural constituent of ribosomeBiological Process: cellular response to insulin stimulus; mitochondrial DNA replication; mitochondrial genome maintenance; mitochondrial signaling pathway; mitochondrion organization and biogenesis; positive regulation of cell growth; positive regulation of cell proliferation; pyrimidine nucleotide transport; regulation of mitochondrial membrane potential; regulation of oxidative phosphorylation; transcription from mitochondrial promoter; translation |
| UniProt Protein Details: | |
| NCBI Summary: | SLC25A33 belongs to the SLC25 family of mitochondrial carrier proteins (Haitina et al., 2006 [PubMed 16949250]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BSK2 |
| NCBI GenInfo Identifier: | 14150082 |
| NCBI Gene ID: | 84275 |
| NCBI Accession: | NP_115691.1 |
| UniProt Secondary Accession: | Q9BSK2 |
| UniProt Related Accession: | Q9BSK2 |
| Molecular Weight: | 35,375 Da |
| NCBI Full Name: | solute carrier family 25 member 33 |
| NCBI Synonym Full Names: | solute carrier family 25 (pyrimidine nucleotide carrier), member 33 |
| NCBI Official Symbol: | SLC25A33Â Â |
| NCBI Official Synonym Symbols: | PNC1; BMSC-MCPÂ Â |
| NCBI Protein Information: | solute carrier family 25 member 33 |
| UniProt Protein Name: | Solute carrier family 25 member 33 |
| UniProt Synonym Protein Names: | Bone marrow stromal cell mitochondrial carrier protein; BMSC-MCP; HuBMSC-MCP; Protein PNC1 |
| Protein Family: | Solute carrier family |
| UniProt Gene Name: | SLC25A33Â Â |
| UniProt Entry Name: | S2533_HUMAN |
