SLC25A3 Antibody (PACO20493)
- SKU:
- PACO20493
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC25A3 Antibody (PACO20493)
The SLC25A3 Polyclonal Antibody (PACO20493) is an essential tool for researchers studying SLC25A3, a mitochondrial protein involved in energy metabolism and cell survival. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the SLC25A3 protein, this antibody allows for the detection and analysis of SLC25A3 levels in a variety of cell types, making it a valuable tool for studies in bioenergetics, mitochondrial function, and cell metabolism.SLC25A3, also known as the phosphate carrier protein, plays a crucial role in the transport of inorganic phosphate across the inner mitochondrial membrane, contributing to ATP production and cellular respiration.
Dysregulation of SLC25A3 has been linked to various metabolic disorders and diseases, making it a target of interest in research on cancer, neurodegenerative diseases, and metabolic syndromes. Understanding the function and regulation of SLC25A3 is essential for uncovering its role in health and disease and for developing targeted therapies for related conditions.
| Antibody Name: | SLC25A3 Antibody (PACO20493) |
| Antibody SKU: | PACO20493 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human SLC25A3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20493(SLC25A3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20493(SLC25A3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. |
| Synonyms: | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 |
| UniProt Protein Function: | SLC25A3: Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). Defects in SLC25A3 are a cause of mitochondrial phosphate carrier deficiency (MPCD). MPCD is a fatal disorder of oxidative phosphorylation. Patients have lactic acidosis, hypertrophic cardiomyopathy and muscular hypotonia and die within the first year of life. Belongs to the mitochondrial carrier family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Mitochondrial; TransporterChromosomal Location of Human Ortholog: 12q23Cellular Component: membrane; mitochondrion; integral to plasma membrane; mitochondrial inner membraneMolecular Function: phosphate carrier activity; symporter activity; protein complex bindingBiological Process: generation of precursor metabolites and energy; transportDisease: Mitochondrial Phosphate Carrier Deficiency |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q00325 |
| NCBI GenInfo Identifier: | 4505775 |
| NCBI Gene ID: | 5250 |
| NCBI Accession: | NP_002626.1 |
| UniProt Secondary Accession: | Q00325 |
| UniProt Related Accession: | Q00325 |
| Molecular Weight: | 39 kDa |
| NCBI Full Name: | phosphate carrier protein, mitochondrial isoform b |
| NCBI Synonym Full Names: | solute carrier family 25 member 3 |
| NCBI Official Symbol: | SLC25A3Â Â |
| NCBI Official Synonym Symbols: | PHC; PTP; OK/SW-cl.48Â Â |
| NCBI Protein Information: | phosphate carrier protein, mitochondrial |
| UniProt Protein Name: | Phosphate carrier protein, mitochondrial |
| UniProt Synonym Protein Names: | Phosphate transport protein; PTP; Solute carrier family 25 member 3 |
| Protein Family: | |
| UniProt Gene Name: | SLC25A3Â Â |
| UniProt Entry Name: | MPCP_HUMAN |
| Antibodies |
| SLC25A3 Antibody (PACO12269) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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