SLC25A21 Antibody (PACO23449)
- SKU:
- PACO23449
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
SLC25A21 Antibody (PACO23449)
The SLC25A21 Antibody (PAC023449) is a specialized tool for studying the SLC25A21 protein, which is involved in mitochondrial function and metabolism regulation. This polyclonal antibody is produced in rabbits and is highly specific for detecting SLC25A21 in human samples. Validated for use in Western blot applications, this antibody binds to the SLC25A21 protein, allowing for accurate detection and analysis in a variety of cell types.SLC25A21, also known as the mitochondrial oxoglutarate carrier, plays a crucial role in cellular energy production and metabolism by transporting metabolites across the inner mitochondrial membrane.
Research on SLC25A21 is essential for understanding mitochondrial function and its impact on cellular processes such as energy production and metabolism regulation. This antibody is an invaluable tool for investigations in areas such as bioenergetics, metabolism, and mitochondrial disorders, providing insights into diseases like cancer, metabolic disorders, and neurodegenerative conditions.
| Antibody Name: | SLC25A21 Antibody (PACO23449) |
| Antibody SKU: | PACO23449 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from internal of human SLC25A21. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HepG2 cells, using SLC25A21 antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using SLC25A21 antibody. |
| Background: | Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate. |
| Synonyms: | mgc126570; odc; odc1; oxodicarboxylate carrier; slc25a21 |
| UniProt Protein Function: | SLC25A21: Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate. Belongs to the mitochondrial carrier family.Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Mitochondrial; Transporter, SLC familyChromosomal Location of Human Ortholog: 14q11.2Cellular Component: mitochondrial inner membrane; integral to membraneBiological Process: lysine catabolic process; transmembrane transport |
| UniProt Protein Details: | |
| NCBI Summary: | SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM, Apr 2004] |
| UniProt Code: | Q9BQT8 |
| NCBI GenInfo Identifier: | 283837920 |
| NCBI Gene ID: | 89874 |
| NCBI Accession: | NP_001164641.1 |
| UniProt Secondary Accession: | Q9BQT8 |
| UniProt Related Accession: | Q9BQT8 |
| Molecular Weight: | |
| NCBI Full Name: | mitochondrial 2-oxodicarboxylate carrier isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 25 member 21 |
| NCBI Official Symbol: | SLC25A21Â Â |
| NCBI Official Synonym Symbols: | ODC; ODC1Â Â |
| NCBI Protein Information: | mitochondrial 2-oxodicarboxylate carrier |
| UniProt Protein Name: | Mitochondrial 2-oxodicarboxylate carrier |
| UniProt Synonym Protein Names: | Solute carrier family 25 member 21 |
| Protein Family: | Probable ornithine decarboxylase |
| UniProt Gene Name: | SLC25A21Â Â |
| UniProt Entry Name: | ODC_HUMAN |
| Antibodies |
| SLC25A21 Antibody (PACO01200) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
SLC25A21 Antibody (PACO01200)
$323
SEZ6 Antibody (PACO64941)
$407
TTC14 Antibody (PACO64997)
$407
ompF Antibody (PACO64865)
$407
ANKEF1 Antibody (PACO64597)
$407
CYP2A13 Antibody (PACO64657)
$383
HNRRabbit Polyclonal Antibody Rabbit Polyclonal Antibody (CAB17497)
$167 - $503